How do metabolic diseases occur? In fact, there are four aspects of responsibility and it is time to change

As we age, our organs decline and our risk of chronic metabolic clinic and metabolic diseases increases dramatically, such as obesity, steatosis, type 2 diabete...

Mar 23,2022 | SERENA

As we age, our organs decline and our risk of chronic metabolic clinic and metabolic diseases increases dramatically, such as obesity, steatosis, type 2 diabetes and atherosclerosis. The common cause is obesity caused by unhealthy lifestyle, so let's take a closer look.

How do metabolic diseases happen?

1. Bad habits

High-sugar and high-fat diets, overeating all the time, and lack of physical activity can lead to overnutrition and obesity, which are the common development causes of metabolic diseases in enterprises. Especially for the accumulation of too much fat in the abdomen, it can increase insulin resistance, which will continue to exacerbate metabolic dysfunction, promote fat accumulation, and eventually we enter a vicious circular economic state.

2. Hyperglycemia and Hyperlipidemia

Insulin resistance is an independent risk factor for various diseases, such as triple high levels, diabetes, stroke and coronary heart disease. Type II diabetes occurs when insulin resistance makes blood sugar difficult to control. In addition, lipolysis is reduced, free fatty acids, bad cholesterol and triglyceride levels are increased, and even high blood pressure and atherosclerosis.

3. Liver and kidney damage

The study found that obese human adipose tissue contains a large number of macrophages, which can trigger an inflammatory response; macrophages colonize different parts of the body, thereby releasing a large number of inflammatory mediators. If macrophages accumulate in the liver, they can cause hepatic lipogenesis, cause an inflammatory response, interfere with sugar and fat metabolism, and aggravate metabolic disorders;

Insulin resistance, coupled with inflammation, can rebuild blood vessels, cause renal parenchyma damage, increase glomerular permeability, cause renal ischemia, accelerate kidney damage, and vascular success also accelerates the atherosclerotic process, causing cardiovascular and cerebrovascular diseases.

4. Imbalance of intestinal flora

Intestinal flora plays an important role in the body, but poor diet, abuse of antibiotics, and staying up late will disturb the balance of intestinal flora, easily cause endotoxemia, cause chronic low-grade inflammation, and then induce metabolic syndrome.